Technique

Developmental biology

  • Appl. Phys. Lett. 102: 043703 (2013) M. Papi, A. Maiorana, C. Douet, G. Maulucci, T. Parasassi, R. Brunelli, G. Goudet, M. De Spirito, "Viscous forces are predominant in the zona pellucida mechanical resistance"
  • Biology Open 2: 1279–1287 (2013) A. Dzementsei, D. Schneider, A. Janshoff, T. Pieler, "Migratory and adhesive properties of Xenopus laevis primordial germ cells in vitro"
  • J. Cell Sci jcs.095596 (2012) C. Lee-Thedieck, N. Rauch, R. Fiammengo, G. Klein, J.P. Spatz, "Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility"
  • J. Mol. Recognit. 25: 262-269 (2012) P. Bertoncini, S. Le Chevalier, S. Lavenus, P. Layrolle, G. Louarn, "Early adhesion of human mesenchymal stem cells on TiO2 surfaces studied by single-cell force spectroscopy measurements"
  • Development 138: 3377-3386 (2011) B. Hampoelz, Y. Azou-Gros, R. Fabre, O. Markova, P.H. Puech, T. Lecuit, "Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos"
  • PlosBiology 8 (11): e1000544 (2010) A. Diz-Muñoz, M. Krieg, M. Bergert, I. Ibarlucea-Benitez, D.J. Müller, E. Paluch, C.P. Heisenberg, "Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment"
  • Nature Cell Biology 10(4): 429-436 (2008) M. Krieg, Y. Arboledo-Estudillo, P.H. Puech, J. Käfer, F. Graner, D.J. Mueller, C.-P. Heisenberg "Tensile forces govern germ-layer organization in Zebrafish"
  • J. Cell Sci. 118: 4199-4206 (2005) P.-H. Puech, A. Taubenberger, F. Ulrich, M. Krieg, D.J. Muller, C.-P. Heisenberg "Measuring cell adhesion forces of primary gastrulating cells from zebrafish using atomic force microscopy"
  • Developmental Cell 9: 555-564 (2005) F. Ulrich, M. Krieg, E.-M.Schötz, V. Link, I. Castanon, V. Schnabel, A. Taubenberger, D. Mueller, P.-H. Puech, C.-P. Heisenberg, "Wnt11 Functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin"

Cancer research

  • Biosensors and Bioelectronics 58: 68–74 (2014) C. Song, G. Xie, L. Wang, L. Liu, G. Tian, H. Xiang, "DNA-based hybridization chain reaction for an ultrasensitive cancer marker EBNA-1 electrochemical immunosensor"
  • J. Mol. Recognit. 25: 270-277 (2012) A. Mescola,, S. Vella, M. Scotto, P. Gavazzo, C. Canale, A. Diaspro, A. Pagano, M. Vassalli, "Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy"
  • Int. J. Cancer 128 (9): 2096–2104 (2011) S.C. Hoffmann, G. Wabnitz, Y. Samstag, G. Moldenhauer, Th. Ludwig, "Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy"
  • J. Immunology 186 (5): 2757-2764 (2011) S.C. Hoffmann, A. Cohnen, Th. Ludwig, C. Watzl, "2B4 Engagement Mediates Rapid LFA-1 and Actin-Dependent NK Cell Adhesion to Tumor cells as measured by Single-Cell Force Spectroscopy"
  • Biochem.Biophys. Research Commun. 402 (2): 361-366 (2010) D. Docheva, D. Padula, M. Schieker, H. Clausen-Schaumann, "Effect of Collagen I and fibronectin on the adhesion, elasticity and cytoskeletal organization of prostate cancer cells"
  • Mol. Cancer Res. 8: 1297-1309 (2010) M. Heroult, F. Schaffner, D. Pfaff, C. Prahst, R. Kirmse, S. Kutschera, M. Riedel, T. Ludwig, P. Vajkoczy, R. Graeser, H.G. Augustin, "EphB4 promotes site-specific metastatic tumor cell dissemination by interacting with endothelial cell expressed ephrinB2"

Cell adhesion

  • Nanomedicine: Nanotechnology, Biology and Medicine 12: 1013-1021 (2016) E. Siamantouras, C.E. Hills, P.E. Squires and K.-K. Liu, "Quantifying cellular mechanics and adhesion in renal tubular injury using single cell force spectroscopy"
  • FEBS Letters 588: 3639-3648 (2014) R. Schubert, N. Strohmeyer, M. Bharadwaj, S.P. Ramanathan, M. Krieg, J. Friedrichs, C.M. Franz and D.J. Müller, "Assay for characterizing the recovery of vertebrate cells for adhesion measurements by single-cell force spectroscopy"
  • Langmuir 30 (14): 4019–4025 (2014) G. Zeng, T. Müller, R.L. Meyer, "Single-cell force spectroscopy of bacteria enabled by naturally derived proteins"
  • Biomaterials 35 (6): 1907–1913 (2014) L.H. Friedrich, P. Jungebluth, S. Sjöqvist, V. Lundin, J.C. Haag, G. Lemon, Y. Gustafsson, F. Ajalloueian, A. Sotnichenko, H. Kielstein, M.A. Burguillos, B. Joseph, A.I. Teixeira, M.L. Lim, P. Macchiarini, "Preservation of aortic root architecture and properties using a detergent-enzymatic perfusion protocol"
  • J. Mol. Biol. 425: 2988–3006 (2013) M.A. Müller, J. Opfer, L. Brunie, L.A. Volkhardt, E.-K. Sinner, D. Boettiger, A. Bochen, H. Kessler, K.-E. Gottschalk, U. Reuning, "The Glycophorin A transmembrane sequence within Integrin αvβ3 creates a non-signaling Integrin with low basal affinity that is strongly adhesive under force"
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833 (12): 3396–3404 (2013) D.M. Poitz, F. Stölzel, L. Arabanian, J. Friedrichs, D. Docheva, M. Schieker, F.A. Fierro, U. Platzbecker, R. Ordemann, C. Werner, M. Bornhäuser, R.H. Strasser, G. Ehninger, T. Illmer, "MiR-134-mediated β1 integrin expression and function in mesenchymal stem cells"
  • Biotechnology and Bioengineering 110 (8): 2301–2310 (2013) E. Migliorini, J. Ban, G. Grenci, L. Andolfi, A. Pozzato, M. Tormen, V. Torre, M. Lazzarino, "Nanomechanics controls neuronal precursors adhesion and differentiation"
  • Tissue Engineering Part B Rev. Jul 10 (2013) A.V. Taubenberger, D.W. Hutmacher, D.J. Müller, "Single-Cell Force Spectroscopy, an Emerging Tool to Quantify Cell Adhesion to Biomaterials"
  • Methods 60 (2): 186–194 (2013) M.P. Stewart, A.W. Hodel, A. Spielhofer, C.J. Cattin, D.J. Müller, J. Helenius, "Wedged AFM-cantilevers for parallel plate cell mechanics"
  • Langmuir 29 (21): 6429–6433 (2013) M. Mishima, S. Ryu, Y. Arai, M. Okose, Y.R. Silberberg, S. Ramachandra Rao, C. Nakamura, "Controlled Cell Adhesion Using a Biocompatible Anchor for Membrane-Conjugated Bovine Serum Albumin/Bovine Serum Albumin Mixed Layer"
  • Biosensors and Bioelectronics 48: 172–179 (2013) C. Canale, A. Petrelli, M. Salerno, A. Diaspro, S. Dante, "A new quantitative experimental approach to investigate single cell adhesion on multifunctional substrates"
  • Acta Biomaterialia 9: 5031–5039 (2013) J. Teichmann, M. Valtink, S. Gramm, M. Nitschke, C. Werner, R.H.W. Funk, K. Engelmann, "Human corneal endothelial cell sheets for transplantation: Thermo-responsive cell culture carriers to meet cell-specific requirements"
  • Nano Lett. 13 (6): 2937–2946 (2013) J. Beckmann, R. Schubert , R. Chiquet-Ehrismann , D.J Müller, "Deciphering Teneurin Domains That Facilitate Cellular Recognition, Cell–Cell Adhesion, and Neurite Outgrowth Using Atomic Force Microscopy-Based Single-Cell Force Spectroscopy"
  • PLoS ONE 8 (3): e57813 (2013) S.A. Braybrook, A. Peaucelle, "Mechano-Chemical Aspects of Organ Formation in Arabidopsis thaliana: The Relationship between Auxin and Pectin"
  • Plasma Process. Polym. 10 (1): 19–28 (2013) A.M. Sandstrom, M. Jasieniak, H.J. Griesser, L. Grøndahl, J.J. Cooper-White, "Effects of Varying Heptylamine and Propionaldehyde Plasma Polymerization Parameters on Mesenchymal Stem Cell Attachment"
  • Phys. Rev. Lett. 110: 018102 (2013) P. Steffen, C. Verdier, C. Wagner, "Quantification of Depletion-Induced Adhesion of Red Blood Cells"
  • Journal of Biomedical Materials Research Part A 101A (4): 981–990 (2012) P. Aliuos, E. Fadeeva, M. Badar, A. Winkel, P.P. Mueller, A. Warnecke, B. Chichkov, T. Lenarz, U. Reich, G. Reuter, "Evaluation of single-cell force spectroscopy and fluorescence microscopy to determine cell interactions with femtosecond-laser microstructured titanium surfaces"
  • Macromol. Rapid Commun. 33: 1453-1458 (2012) J. Friedrichs, A. Zieris, S. Prokoph, C. Werner, "Quantifying the Effect of Covalently Immobilized Enzymes of Biofilm Formation by Atomic Force Microscopy-Based Single Cell Force Spectroscopy"
  • J. Mol. Recognit. 25: 262-269 (2012) P. Bertoncini, S. Le Chevalier, S. Lavenus, P. Layrolle, G. Louarn, "Early adhesion of human mesenchymal stem cells on TiO2 surfaces studied by single-cell force spectroscopy measurements"
  • J. Mol Recognit. 25: 270-277 (2012) A. Mescola,, S. Vella, M. Scotto, P. Gavazzo, C. Canale, A. Diaspro, A. Pagano, M. Vassalli, "Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy"
  • Exp. Cell Res. 318: 2155-2167 (2012) L. Dao, U. Weiland, M. Hauser, I. Nazarenko, H. Kalt, M. Bastmeyer, C.M. Franz, "Revealing non-genetic adhesive variations in clonal populations by comparative single-cell force spectroscopy"
  • Coll. Surf. B 15: 82-89 (2012) P. Elter, T. Weihe, S. Bühler, J. Gimsa, U. Beck, "Low fibronectin concentration overcompensates for reduced initial fibroblasts adhesion to a nanoscale topography: Single-cell force spectroscopy"
  • Cell Calcium 50 (1): 54-61 (2011) P. Steffen, A. Jung, D.B. Ngyen, T. Müller, I. Bernhardt, L. Kästner, Ch. Wagner, "Stimulation of red blood cells leads to Ca2+ mediated intercellular adhesion"
  • Nano Lett. 11: 1469-1476 (2011) J.A. Deeg, I. Louban, D. Aydin, C. Selhuber-Unkel, H. Kessler, J.P. Spatz, "Impact of Local versus Global Ligand Density on Cellular Adhesion"
  • The FASEB Journal 25(2), 624-631 (2011) Y.-B. Lu, I. Iandiev, M. Hollborn, N. Körber, E. Ulbricht, P. G. Hirrlinger, Th. Pannicke, Er-Q. Wei, A. Bringmann, H. Wolburg, U. Wilhelmsson, M. Pekny, P. Wiedemann, A. Reichenbach, J. A. Käs, "Reactive glial cells: increased stiffness correlates with increased intermediate filament expression"
  • Nature Medicine 17: 479–487 (2011) T.K. Flach, G. Ng, A. Hari, M. Desrosiers, P. Zhang, S. Ward, M. Seamone, A. Vilaysane, A. Mucsi, Y. Fong, E. Prenner, Ch. Ling, J. Tschopp, D. Muruve, M. Amrein, Y. Shi, "Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity"
  • J.Phys: Condens. Matter 22 (19): 194101 (2010) D. Boettiger, B. Wehrle-Haller, "Integrin and glycocalyx mediated contributions to cell adhesion identified by single cell force spectroscopy"
  • Biophys. J. 98 (4): 543-551 (2010) C. Selhuber-Unkel, T. Erdmann, M. Lopez-Garcia, H. Kessler, U.S. Schwarz, J. P. Spatz, "Cell Adhesion Strength is controlled by intermolecular spacing of adhesion receptors"
  • Biomaterials 31 (25): 6436-6443 (2010) G. Weder, O. Guillaume-Gentil, N. Matthey, F. Montagne, H. Heizelmann, J. Vörös, "The quantification of single cell adhesion on functionalized surfaces for cell sheet engineering"
  • Langmuir 26 (11): 8180-8186 (2010) G. Weder, N. Blondiaux, M. Giazzon, , N. Matthey, M. Klein, R. Pugin, H. Heinzelmann, M. Liley, "Use of Force Spectroscopy to Investigate the Adhesion of Living Adherent Cells"
  • Proteomics 10: 1455-1462 (2010) J. Friedrichs, J. Helenius, D.J. Mueller, "Stimulated single-cell force spectroscopy to quantify cell adhesion receptor crosstalk"
  • Biointerphases 4(2): 27-34 (2009) G. Weder, J. Vörös, M. Giazzon, N. Matthey, H. Heinzelmann, M. Liley, "Measuring cell adhesion forces during the cell cycle by force spectroscopy"
  • Microscopy Research and Technique 72(12): 957-964 (2009) Veronica Saravia, José L. Toca-Herrera, "Substrate influence on cell shape and cell mechanics: HepG2 cells spread on positively charged surfaces"
  • J. Cell Sci. 121: 877-886 (2008) P. Pittet, K. Lee, A.J. Kulik, J.-J. Meister, B. Hinz, "Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds"
  • J. Mol. Biol. 377 (4): 1082-1093 (2008) F.A. Fierro, A. Taubenberger, P.-H. Puech, G. Ehninger, M. Bornhauser, D.J. Muller, T. Illmer, "BCR/ABL expression of myeloid progenitors increases β1-integrin mediated adhesion to stromal cells"
  • Biophysical Journal 95(11): 5424-5431 (2008) Ch. Selhuber-Unkel, M. Lopez-Garcia, H. Kessler, J.P. Spatz, "Cooperativity in Adhesion Cluster Formation during Initial Cell Adhesion"
  • Mol. Biol. Cell 18 (5): 1634-1644 (2007) A. Taubenberger, D.A. Cisneros, J. Friedrichs, P.-H. Puech, D.J. Muller, C.M. Franz, "Revealing early steps of {alpha}2beta1 integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy"
  • J. Biol. Chem. 282 (40): 29375-29383 (2007) J. Friedrichs, J.M. Torkko, J. Helenius, T.P. Teräväinen, J. Füllekrug, D.J. Müller, K. Simons, A. Manninen, "Contributions of Galectin-3 and -9 to epithelial cell adhesion analysed by single cell force spectroscopy"

Cell Mechanics / Cell Motility

  • PNAS 112: 11258-11263 (2015) C.J. Cattin, M. Düggelin, D. Martinez-Martin, C. Gerber, D.J. Müller and M.P. Stewart, "Mechanical control of mitotic progression in single animal cells"
  • Integrative Biology 7: 356-363 (2015) C. Gonnermann, C. Huang, S.F. Becker, D.R. Stamov, D. Wedlich, J. Kashef and C.M. Franz, "Quantitating membrane bleb stiffness using AFM force spectroscopy and an optical sideview setup"
  • Science 338 (6104): 260-263 (2012) R.C. Hardie, K. Franze, "Photomechanical Response in Drosophila Photoreceptors"
  • J Cell Sci jcs.095596 (2012) C. Lee-Thedieck, N. Rauch, R. Fiammengo, G. Klein, J.P. Spatz, "Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility"
  • J Cell Sci. 125: 603-613 (2012) L. Guolla, M. Bertrand, K. Haase, A.E. Pelling, "Force transduction and strain dynamics in actin stress fibres in response to nanonewton forces"
  • Nat. Protoc. 7: 143-154 (2012) M.P. Stewart, Y. Toyoda, A.A. Hyman, D.J. Müller, "Tracking mechanics and volume of globular cells with atomic force microscopy using a constant-height clamp"
  • Adv. Mat. Res. 463-464: 748-752 (2012) K.L. Wong, A.H.W. Ngan, D.K.Y. Shum, W.W. Lu, "Nanomechanical properties of Vimentin intermediate filament"
  • Nanomedicine: Nanotechnology, Biology and Medicine 8: 17-19 (2012) P. Eaton, V. Zuzarte-Luis, M.M. Mota, N.C. Santos, M. Prudencio, "Infection by Plasmodium changes shape and stiffness of hepatic cells"
  • Nanotechnology 22: 345102 (2011) A.R. Harris, G.T. Charras, "Experimental validation of atomic force microscopy-based cell elasticity measurements"
  • J. Mech. Behav. Mater. 8: 134-142 (2011) Z.L. Zhou A.H.W. Ngan B. Tang, A.X. Wang, "Reliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscope"
  • Small 7: 1480-1487 (2011) J. Zahn, I. Louban, S. Jungbauer, M. Bissinger, D. Kaufmann, R. Kemkemer, J.P. Spatz, "Age-dependent changes in microscale stiffness and mechanoresponses of cells"
  • Development 138: 3377-3386 (2011) B. Hampoelz, Y. Azou-Gros, R. Fabre, O. Markova, P.H. Puech, Th. Lecuit, "Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos"
  • Arterioscler. Thromb. Vasc. Biol. 31: 1007-1010 (2011) A. Broisat, J. Toczek, N. Meisner, P. Tracqui, C. Ghezzi, J. Ohayon, L.M. Riou, "Assessing low levels of mechanical stress in aortic atherosclerotic lesions from apolipoprotein E-/- mice--brief report"
  • Nature 469: 226-231 (2011) M. P. Stewart, J. Helenius, Y. Toyoda, S.P. Ramanathan, D.J. Müller, A.A. Hyman, "Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding"
  • J. Structural Biology 174 (1): 115-123 (2011) P. Traqui, A. Broisat, J. Toczek, N. Mesnier, J. Ohayon, L. Riou, "Mapping elasticity moduli of atherosclerotic plaque in situ via atomic force microscopy"
  • Soft Matter 7: 3147-3154 (2011) K. Franze, M. Francke, K. Günter, A.F. Christ, N. Körber, A. Reichenbach, J. Guck, "Spatial mapping of the mechanical properties of the living retina using scanning force microscopy"
  • Nanomedicine 8:355-364 (2011) S.T. Buckley, C. Medina, A.M. Davies, C. Ehrhardt, "Cytoskeletal re-arrangement in TGF-β1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis"
  • Cytoskeleton 67: 555-563 (2010) O. Jonas, C. Duschl, "Force propagation and Force Generation in Cells"
  • J. Cell Sci. 123: 1751-1760 (2010) L.F. Castella, L. Buscemi, C. Godbout, J.J. Meister, B. Hinz, "A new lock-step mechanism of matrix remodelling based on subcellular contractile events"
  • J. Biomechanics 43 (16): 3091-3098, (2010) J. Desrochers, M.A. Amrein, J.R. Maytas, "Structural and functional changes of the articular surface in a post-traumatic model of early osteoarthritis measured by atomic force microscopy"
  • J. Biomechanics 43 (15): 2986-2992 (2010) A.F. Christ, K. Franze, H. Gautier, P. Moshayedi, J. Fawcett, R.J.M. Franklin, R.T. Karadottir, J. Guck, "Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy"
  • PNAS 107 (49): 21016-21021 (2010) A. Labernadie, C. Thibault, C. Vieu, I. Maridonneau-Parini, G.M. Charrière, "Dynamics of podosome stiffness revealed by atomic force microscopy"
  • Biochemical and Biophysical Research Communications 401 (1): 143-148 (2010) A. Marg, H. Haase, T. Neumann, M. Kouno, I. Morano, "AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness "
  • Cell Motility and the Cytoskeleton 66: 193-201, 2009 Schulze C., Müller K., Käs J.A., Gerdelmann J.C., "Compaction of cell shape occurs before decrease of elasticity in CHO-K1 cells treated with actin cytoskeleton disrupting drug Cytochalasin D"
  • Current Biology 18: 91-101 (2008) P. Kunda, A.E. Pelling, T. Liu, B. Baum, "Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis"
  • J.Cell. Mol. Med. 12 (2): 537-552 (2008) D. Docheva, D. Padula, C. Popov, W. Mutschler, H. Clausen-Schaumann, M. Schieker, "Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy"
  • J. Mol. Recognit. 20: 1-9 (2007) A.E. Pelling, F.S. Veraitch, C. Chu, B.M. Nicholls, A.L. Hemsley, C.Mason, M.A. Horton, "Mapping correlated membrane pulsations and fluctuations in human cells"
  • Ultramicroscopy 107 (10): 948-953 (2007) Z. Leonenko, E. Finot, M. Amrein, "Adhesive interaction measured between AFM probe and lung epithelial type II cells"
  • PNAS 103: 17759-17764 (2006) Y.-B. Lu, K. Franze, G. Seifert, C. Steinhäuser, F. Kirchhoff, H. Wolburg, J. Guck, P.Janmey, E.-Q. Wei, J. Käs, A. Reichenbach, "Viscoelastic properties of individual glial cells and neurons in the CNS"
  • Eur. Biophys. J. 35 (8): 713-719 (2006) C.A. Brunner, A. Ehrlicher, B. Kohlstrunk, D. Knebel, J.A. Käs, M. Goegler, "Cell migration through small gaps",

Immunology

  • PLoS One. 2011; 6(7): e22344 P.H. Puech, D. Nevoltris, P. Robert, L. Limozin, C. Boyer, P. Bongrand, "Force Measurements of TCR/pMHC Recognition at T Cell Surface"
  • Immunology letters 136 (1): 13-20 (2011) S. Hoffmann, B.H. Hosseini, M. Hecker, I. Louban, N. Bulbuc, N. Garbi, G.H. Wabnitz, Y. Samstag, J.P. Spatz, G.J. Hämmerling, "Single cell force spectroscopy of T cells recognizing a myelin-derived peptide on antigen presenting cells"
  • Arteriosclerosis, Thrombosis, and Vascular Biology 31 (2): 297-305 (2011) J. Braun, S. Hoffmann, A. Feldner, Th. Ludwig, R. Henning, M. Hecker, Th. Korff, "Endothelial Cell EphrinB2-Dependent Activation of Monocytes in Arteriosclerosis"
  • PNAS 106/42 : 17852-17857 (2009) B. H. Hosseini et al., "Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy"
  • Immunity 29: 1-12 (2008) G. Ng, K. Sharma, S.M. Ward, M.D. Desrosiers, L.A. Stephens, W.M. Schoel, T. Li, C.A. Lowell, C.-C. Ling, M. W. Amrein, Y. Shi, "Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dentritic Cells"

Tether Pulling and tether characterization