The Catholic University of Rome uses the JPK NanoWizard® AFM & CellHesion® systems to understand how cells sense and respond to mechanical stimuli.
Dr Gabriele Ciasca and Professor Massimiliano Papi are members of the research team of Professor Marco De Spirito in the Institute of Physics at the Catholic University of Rome, Italy. One of the main goals of their group is the investigation of how cells sense and respond to physical and mechanical stimuli.
JPK’s NanoWizard® AFM systems are used at the University of Sheffield to understand soft matter and biological systems at the molecular scale.
The research of the SPM group of Prof. Jamie Hobbs is based around instrument development for scanning probe microscopy for the study of soft matter and biological systems at the molecular scale. As well as applying existing methods and instrumentation, the group have the added challenge to develop new equipment and protocols to allow the study of different samples at higher magnifications applying new detection systems.
JPK reports on the use of STM to study surface plasmons in the Molecular Science Group at ISMO – Institut des Sciences Moléculaires d’Orsay
Dr Elizabeth Boer-Duchemin leads the Molecular Nanoscience Group at ISMO. One of the research goals of the group is to work towards circuits and devices in which surface plasmons (not electrons or photons) are used to transfer and manipulate information.
JPK’s NanoTracker™ 2 optical tweezers system is used in the Modesti group at the Centre for Cancer Research, INSERM, to manipulate individual DNA molecules
The research team lead by Dr Mauro Modesti at the Centre for Cancer Research, Marseilles (CRCM), focuses on the study and understanding of the molecular mechanisms that assure DNA repair and the maintain of genome integrity in human cells.
JPK’s NanoWizard® AFM and CellHesion® systems are used to shed light on the development and regeneration of the central nervous system in the Franze group at the University of Cambridge
Dr Kristian Franze is a lecturer in the Department of Physiology, Development and Neuroscience at the University of Cambridge. His major goal is to understand when, where and how mechanical signals, such as forces and local tissue stiffness, are involved in controlling cell development and function in the nervous system.
JPK’s NanoWizard® AFM is used to evaluate the risk of cardiovascular disease in patients at iMM, University of Lisbon
Dr Nuno C Santos leads the Biomembranes and Nanomedicine group at the Institute of Molecular Medicine at the University of Lisbon, Portugal. Driven by the fact that cardiovascular diseases are the leading cause of mortality worldwide, accounting for about one third of all deaths and that biomarkers for assessing cardiovascular risk still have a limited applicability, there is much potential for research into new solutions. High levels of fibrinogen, a protein essential for the blood clotting process, have been identified as a potential risk factor for these diseases and it is this topic that the group has applied atomic force microscopy (AFM) to study.
The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins.
Dr Gordon McPhee is head of production for NextCell Pty in Adelaide, Australia. Situated on the Mawson Lakes Campus, he is located next to the University of South Australia (UniSA), Australia’s leading university for interdisciplinary research, where he has access to their instrumentation as part of the group of Professor Nico Voelcker at the Future Industries Institute. Here, he uses JPK’s NanoWizard® AFM system in multiple programs.
JPK’s NanoWizard® AFM and ForceRobot® systems are being used in the field of medical diagnostics in the Supersensitive Molecular Layer Laboratory of POSTECH in Korea.
Professor Joon Won Park is head of the Supersensitive Molecular Laboratory at Korea’s Pohang University of Science & Technology. His group’s research goal is to bring AFM into the field of medical diagnostics. It is their belief that AFM is the most sensitive tool for detecting various biomarkers without amplification or labelling. Reliability and speed have been past hurdles of AFM, but Professor Park’s team has demonstrated that the application of a finely controlled surface coating to AFM probes and substrates overcomes this barrier.
JPK’s NanoWizard® AFM system is being used for cell studies in the Research Centre for Nanometer-scale Science & Advanced Materials at the Jagiellonian University in Krakow, Poland.
Dr Marek Szymonski is a Professor at the Research Centre for Nanometer-Scale Science and Advanced Materials (NANOSAM) located at the Jagiellonian University in Krakow, Poland. The aim of his research is to understand the signals that govern intracellular communication between hepatocytes and liver sinusoidal endothelial cells (LSECs) and between cardiomyocytes and cardiac microvascular endothelial cells (CMECs).
JPK reports on the use of a NanoWizard® AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces.
The Group uses the JPK NanoWizard® AFM to study the interaction of bacteria with microstructured surfaces. They look at micromilled titanium surfaces. They study the adhesion of single bacteria to the surface and investigate the elastic properties of the bacteria adhered to the surface (for example, as a function of pH). The goal of all these measurements is to find the best surface structure bacteria combination to produce a biofilm reactor.
JPK’s NanoWizard® ULTRA Speed AFM system is being applied to study biological membrane structures and protein dynamics at the University of Liverpool.
Dr Luning Liu leads a research group at the Institute of Integrative Biology at the University of Liverpool. Using interdisciplinary approaches, the Liu Lab aims to explore the molecular mechanism underlying the self-assembly, dynamics and regulation of biological membranes and macromolecular protein complexes.
JPK’s optical tweezers system, the NanoTracker™ 2, is used in the Department of Mechanical Engineering at the Shibaura Institute of Technology, Tokyo, Japan to study micro-bubbles.
Dr Yoko Yamanishi is an Associate Professor in the Department of Mechanical Engineering at Shibaura Institute of Technology, Tokyo, Japan. She leads the Yamanishi Laboratory - the Micro-nano Functional Fluid Laboratory. The Laboratory’s goals aim to clarify unknown function of cells by using micro-nano technology based on mechanical, electrical and bio-medical engineering. It targets a contribution to the development of cellular scale medical treatment.
Multiple uses for the JPK NanoWizard® AFM system in the Smart Interfaces in Environmental Nanotechnology Group at the University of Illinois at Urbana-Champaign.
Dr Rosa M Espinosa-Marzal is an Associate Professor in the Department of Civil & Environmental Engineering at the University of Illinois at Urbana—Champaign. The goal of her research is to design innovative systems and improved materials that can solve environmental problems of our society by applying fundamentals of surface and colloidal science, materials chemistry, and nanotechnology.
Oxford University “Research Hotel” combines the JPK NanoWizard® AFM with a toolbox of microscopy techniques.
Dr Marco Fritzsche works in the Nano-Immunology group of Professor Christian Eggeling in the MRC Human Immunology Unit (HIU) at the WIMM. Their specialty areas include cell mechanics and the use of FRAP. They combine AFM with a toolbox of fluorescence microscopy techniques to investigate the mechanisms of actin cytoskeleton-mediated force generation during triggering of immune cells such as the activation of T-cells.
JPK reports on the multiple uses of the NanoWizard® AFM system at the Korean Research Institute of Chemical Technology (KRICT).
Established in 1976 for R&D of chemical technology in Korea, the Korean Research Institute of Chemical Technology (KRICT) has helped drive the growth of the country’s chemical industry. The focus is on the development of world-class key technologies.
JPK reports on the use of a NanoWizard® AFM-SECM system at the Université Paris Diderot looking at nanoscale biostructures.
Drs Christophe Demaille and Agnès Anne from CNRS work in the Laboratoire d'Electrochimie Moléculaire at the Université Paris Diderot as Group Leaders of a research team aiming to probe electron transport and communication in nanometric biostructures. Their studies are performed at the single nano-object scale using combined atomic force (AFM)-Electrochemical (SECM) microscopy.
JPK reports on the use of SPM in the Messersmith Group at UC Berkeley looking at biologically inspired polymer adhesives.
Dr. Phillip Messersmith is the Class of 1941 Professor in the Departments of Bioengineering and Materials Science and Engineering at the University of California at Berkeley. His research group is interested in understanding structure-processing- property relationships of materials in biological systems, and in using this information to inform the design, synthesis and application of biologically inspired synthetic materials used in a variety of practical applications.
JPK reports the exploration of living cells using nanoscale and single molecule techniques through the application of scanning probe microscopy in the group of Yves Dufrêne at the Catholic University of Louvain, Belgium.
Dr Yves Dufrêne is a senior research fellow who is leading the Nanobio Team at UCL, Université catholique de Louvain. His research is at the cross-roads of nanotechnology and microbiology where the goal is to gain insight into the nanometer-scale surface architecture and molecular interactions of microbes.
JPK reports on the use of the NanoWizard® 3 AFM system at the Hebrew University of Jerusalem
Dr Meital Reches is a senior lecturer in the Institute of Chemistry. The activities in her lab focus on developing new biomolecular self-assembled systems and the study of proteins and peptides interactions with surfaces. The NanoWizard® AFM is used to perform single molecule force spectroscopy measurements.
JPK reports on the use of optical tweezers in the Schieber Research Group at Illinois Institute of Technology
The Schieber Research Group is led by Jay Schieber, Professor of Chemical Engineering at the Illinois Institute of Technology where he is also Director of the Center for Molecular Study of Condensed Soft Matter. Current research focuses on the kinetic theory of macromolecules to model the rheological, thermodynamic and thermal behaviour of polymeric fluids. These models are then used to predict the properties of advanced materials during and after processing.
JPK reports on the use of AFM and the CellHesion® module to study plant cells at the University of Queensland
Dr Gleb Yakubov and his team from the Rheology & Biolubrication Laboratory in the School of Chemical Engineering at the University of Queensland study properties of plant cells, e.g. how mechanical stresses influence their growth and development.
JPK reports on the application of the NanoWizard® AFM system in cancer research at the ITAV Centre in Toulouse
Dr Childérick Severac manages the Bionanotechnologies Platform at ITAV (Institut des Technologies Avancées en science du Vivant) on the site of the new Oncopole campus dedicated to cancer research. His research focuses on the development of soft nanolithography techniques and to develop the concept of a new type of label-free biochip for the prognosis of breast cancer.
JPK reports on the use of the NanoWizard® AFM system at TU Braunschweig to study the properties of DNA and DNA nanostructures
Dr Philip Tinnefeld is Professor of Biophysical Chemistry at the Technische Universität Braunschweig where he runs a laboratory which specialises in the field of NanoBioScience. His group has pioneered the integration of DNA origami with optical single-molecule spectroscopy over the last few years.
JPK reports on the use of the NanoTracker™ Optical Tweezers system at the University of Leiden to study the organisation of genomic DNA
Dr Rosalie Driessen is a post-doctoral researcher in the Laboratory of Molecular Genetics, a part of the Leiden Institute of Chemistry at Leiden University. She is studying the organization and dynamics of bacterial chromatin having received her doctorate from the University for her thesis, “The architects of crenarchaeal chromatin.”
JPK reports on the use of AFM and advanced fluorescence microscopy at the University of Freiburg
The research team of Junior Professor Dr Winfried Römer is located at the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg. Under the title of Synthetic Biology of Signalling Processes, the Römer team studies the interactions of human pathogens (bacteria, viruses) and pathogenic products (toxins) with various human cells by using a highly interdisciplinary research approach at the interface of biology, medicine, physics and chemistry.
JPK reports on the use of the NanoWizard® AFM system at Swansea University to study the structural, chemical, optical and electronic properties of materials on the nanoscale
Dr Peter Dunstan is an associate Professor in the Department of Physics at Swansea University and a member of the University’s Centre for Nanohealth. His research utilizes state of the art techniques and instrumentation to increase the fundamental understanding of the structural, chemical, optical and electronic properties of materials on the nanoscale, and by doing so advance the future application of those materials.
JPK reports on the use of the NanoWizard® AFM system for force measurements at Monash University
Dr Rico Tabor leads the Soft Materials and Colloids Group in the School of Chemistry at Monash University. Research focuses on several areas. At a fundamental level, the group is interested in exploring the interactions that cause aggregation and assembly, in everything from nanoparticles, droplets and graphene to proteins and cells.
JPK reports on the use of Quantitative Imaging (QI™) mode of the NanoWizard® 3 at Niigata University
Professor Kawase from the Institute of Medicine and Dentistry at Niigata University uses QI™ mode and the NanoWizard® 3 AFM to determine the optimal stiffness or elasticity of cell scaffolding materials, and to demonstrate dynamic changes in cytoskeletal fiber formation in response to the mechanical property of scaffolds.
JPK reports on the use of the CellHesion® 200 system to study cellular adhesion at the molecular level at the University of Warwick
Dr Paul Squires and Dr Claire Hills from the School of Life Sciences (SLS) at the University of Warwick have international expertise in cell biology, signalling and endocrinology. They are using the JPK CellHesion® 200 system to study cellular adhesion in the field of diabetes.
JPK reports on the use of the ForceRobot® system to study the dynamics of biomacromolecules at Nanjing University
Professor Yi Cao is a member of the Institute of Biophysics located in the Physics Department of Nanjing University. The main focus of his group is to study how force regulates the structures and conformational dynamics of biomacromolecules using AFM based single molecule force spectroscopy.
JPK reports on the studies of adhesion forces between cancer cells at the Institute of Physiology II at the University of Münster, Germany
Dr Florian T. Ludwig is a member of the team of Professor Albrecht Schwab and Dr Christian Stock. These researchers are interested in how ion transport across the plasma membrane affects tumor cell motility and, thus, metastasis. Together with Mike Wälte from the group of the Head of the Institute, Professor Hans Oberleithner and Dr Hermann Schillers, Dr. Ludwig applies the CellHesion® 200 to measure cell-cell adhesion forces in tumor cells.
JPK reports on the use of the NanoTracker™ Optical Tweezers system at Norway’s NTNU Trondheim
Dr Marit Sletmoen is an associate professor in the Department of Physics. She specialises in the study of biological polymers, biophysics and medical technology and applies the NanoTracker™ Optical Tweezers system in the study of biomacromolecules.
JPK reports on the characterization of nanostructures and nanosized systems using the NanoWizard AFM in the group of Giovanni Dietler at EPFL, Lausanne
Dr Giovanni Longo under the supervision of Professor Giovanni Dietler at the "Laboratory of the Physics of Living Matter"(LPMV) of EPFL uses the NanoWizard® 3 AFM system to study bacterial resistance to antibiotics and the growth of osteoblasts with a focus on their interactions with differently prepared substrates and to different gravity conditions.
JPK reports on the study of structure and dynamics of biological membranes using AFM and advanced fluorescence microscopies at the CBS in Montpellier
Focusing on single molecule physics, Dr Pierre-Emmanuel Milhiet runs a team which applies AFM and advanced fluorescence microscopies (single molecule tracking and single-molecule localization microscopy or SMLM) in the study of both structure and dynamics of biological membranes.
JPK reports on the studies of the nanomechanical properties of biomaterials at Nagoya Institute of Technology in Japan
Professor Shinji Deguchi leads a research group at Nagoya Institute of Technology (NITech). The Laboratory for Mechanobiology & Bioengineering has a multi-disciplinary approach to the growing field of Mechano-Biology. This brings together the areas of cell biology, bioengineering and biophysics.
JPK reports on the developments of high resolution imaging in the group of Takeshi Fukuma at Kanazawa University in Japan
Professor Takeshi Fukuma runs a research group in the Division of Electronic Engineering and Computer Science at Kanazawa University in Japan. The Fukuma Laboratory focuses on molecular-scale analysis and measurements of biological phenomena using atomic force microscopy, AFM.
JPK reports on the use of Quantitative Imaging, QI™, for the study of living bacteria at the Université de Paris-Sud
Dr Christian Marlière leads a research team to study the dynamics and properties (mechanical, electrical and electro-chemical) of living bacteria in purely controlled physiological conditions at nanometer scale: motility or adhesion processes of bacteria on solid substrates, biofilms formation, the influence of light on moving properties of cyanobacteria, effects of antibiotics on bacterial membranes and biofilm etc.
JPK reports on the use of the NanoTracker™ optical tweezers system at the Mechanobiology Institute at the National University of Singapore
The research of the Yan Jie single molecule biophysics research group at NUS is based on highly sensitive single-molecule manipulation and imaging techniques. It also requires understanding mechanics of biopolymers.
JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion® techniques
The Nano-mechanics group develops and uses novel techniques to understand molecular processes and has recently developed new instrumentation in the fields of single molecule force spectroscopy and correlation spectroscopy.
JPK reports on the research activities of the Nanophysics Group at the Istituto Italiano di Tecnologia based in Genova
The research of Professor Alberto Diaspro, Director of the Department of Nanophysics, includes the design, realization and utilization of optical and biophysical instrumentation such as far-field super resolution optical microscopy and nanoscopy, conventional and confocal microscopy, two-photon fluorescence microscopy and spectroscopy architecture, and scanning probe microscopy (STM, SNOM, AFM). This last area has led to collaborations with JPK Instruments.
JPK reports on the applied research of Ioan Notingher at the University of Nottingham using AFM and the Tip Assisted Optics module to study individual nanotubes and fibrils
The research programmes of the Nottingham Nanoscience group span a range of exciting and topical themes in state-of-the-art nanoscale science. Housed in a suite of recently refurbished laboratories containing an excellent equipment base, their core activities are focussed on understanding and controlling the structure and behaviour of condensed matter on length scales ranging from the single molecule limit to micron dimensions.
JPK reports on the use of AFM and single-cell force spectroscopy at the Interdisciplinary Nanoscience Center at Aarhus University, Denmark
The group of Dr Rikke Meyer works at the interface between microbiology and nanoscience in the quest to understand how bacteria form biofilms and how this may be prevented. AFM and optical microscopy are used to visualize bacterial cells and to study the interaction forces between cells and an abiotic substrate. AFM imaging and single-cell force spectroscopy are excellent tools to visualize detailed structures on the bacterial cell surface and to study how these contribute to cell adhesion to other substrates.
JPK reports on the use of Tip Assisted Optics to characterize biomolecular hydrogels at CIC biomaGUNE in San Sebastian, Spain
JPK Instruments reports on the use of their Tip Assisted Optics module by Dr Ralf Richter at the CIC biomaGUNE, Biosurfaces Unit in San Sebastian, Spain. The current research work is centered on biomolecular hydrogels, a broad class of materials that are produced in the human body or by other bioorganisms.
JPK reports on the first images of DNA’s double helix in the molecule’s natural environment by AFM
JPK Instruments reports on the use of AFM systems in the group of Dr Bart Hoogenboom of the London Centre for Nanotechnology. Dr Hoogenboom’s laboratory collaborates with JPK to look at ways to push instrumentation to new limits of resolution and imaging.
JPK reports on the use of their NanoWizard systems in the Microscopy & Imaging Facility at the University of Calgary
JPK Instruments reports on the use of their NanoWizard systems in the Microscopy and Imaging Facility (MIF) at the University of Calgary. Single cell force spectroscopy at the MIF has now attracted high profile research with three NanoWizard® AFM systems from JPK, one of which is equipped with the CellHesion® module.
JPK reports on the biophysical research activities of Dr Michael Higgins of IPRI and ACES at the University of Wollongong in Australia
Dr Higgins’s main interest and research has focused on the application of AFM to study the nanoscale interactions of biological systems, including living cells, model lipid membranes, single ligand-receptor interactions, individual protein unfolding, fundamental surface-force interactions, as well as being involved in AFM instrument development.
JPK reports on the research activities of Dr Jochen Guck and his teams at Dresden & Cambridge Universities
JPK Instruments reports on the multi-faceted research projects of Dr Jochen Guck who runs simultaneous research at the Universities of Dresden and Cambridge.
JPK reports on the current research activities of Dr Clemens Franz and his team at Karlsruhe Institute of Technology
Dr Clemens Franz leads a group of researchers at the DFG-Center for Functional Nanostructures at Karlsruhe Institute of Technology where he works on expanding the use of AFM for cell biological applications.
JPK reports on how graphenes are being studied using AFM to better characterize their properties at the Humboldt University in Berlin
JPK Instruments reports on a keynote paper in Nano Letters where Dr Nikolai Severin and his co-workers from the group of Professor Jürgen Rabe have applied JPK’s NanoWizard® system to improve their understanding of the properties of graphene.
The Nanoscopy Group of Dr Volker Deckert applies JPK platform of optical technologies in the development of TERS
JPK Instruments reports on the research and technique development activities of the Institute of Photonic Technology (IPHT) in Jena under the direction of Dr Volker Deckert. The Nanoscopy department utilizes instrumental methods in the development of molecular spectroscopic methods with the highest spatial resolution. Central to this program has been the use of tip-enhanced Raman scattering (TERS).
The Chemnitz University of Technology selects JPK’s NanoWizard AFM system for the characterization of polymeric and biological materials
JPK Instruments is pleased to report on the research work from the Chemical Physics group of Professor Robert Magerle of the Chemnitz University of Technology. The Chemical Physics Group is part of the Faculty of Natural Sciences. The main research topic is the study of the structure and properties of polymeric materials.
JPK's ForceRobot system produces high volume single molecule force spectroscopy results in Yuri Lyubchenkos group at the University of Nebraska
JPK Instruments reports on the work from the Pharmaceutical Sciences Department of the Medical School at the University of Nebraska. The Department have selected the
JPK ForceRobot® 300 system to extend their studies applying atomic force microscopy, AFM, in the measurement of single molecule force spectroscopy.
The University of Leipzig adds JPK´s CellHesion® 200 capability to enhance cell-cell force measurements
The research of the Institute of Experimental Physics I is focused on soft condensed matter as bulk material, in interaction with surfaces and interfaces, and with
single molecules. The systems under study cover a wealth like small tracer molecules, liquid crystals, polymers, polymer-networks, proteins, and even living biological
cells. It is objective of the research of the Institute of Experimental Physics I to explore the physical basis of structure-property relationships in these systems.
The Karlsruhe Institute of Technology (KIT) uses the JPK NanoWizard family of AFMs for the nanoscale characterization of optical systems and devices
JPK Instruments reports on the work from the Light Technology Institute at the Karlsruhe Institute of Technology (KIT) in Germany where the JPK NanoWizard® family of
AFMs provide the backbone for topographic and optical research activities.
The University of Nottingham selects JPK´s innovative ForceRobot® system for single molecule and biopharmaceutical applications
JPK Instruments is pleased to report on the first work from the University of Nottingham who have chosen the ForceRobot® 300 system for their School of Pharmacy.
JPK Instruments’ NanoWizard® provides valuable information about the Iceman for the Ludwig-Maximilians University in Munich and the European Academy in Bolzano
JPK Instruments reports on the work of the Stark research group at LMU-Munich in cooperation with the EURAC Bolzano where a NanoWizard® AFM system has been used to reveal the nanostructure and mechanics of mummified type I collagen from the 5300-year-old Tyrolean Iceman.