NanoWizard®II from the Pioneers of BioAFM. New Standards for Soft Matter and Life Science AFM. Performance Redefined.

The JPK NanoWizard® AFM paved the way for a multitude of applications in Soft Matter and Life Science research. With German precision engineering and a pioneering spirit, JPK established the BioAFM as a new class of instrumentation with a tremendous global success. There are imitators, but only JPK seriously addresses the needs of life science researchers by concentrating on solutions for their applications. With this strong focus, JPK is the technology leader in this field, and the NanoWizard®II sets a new standard for the next generation BioAFM.

Key BioAFM design criteria

NanoWizard II on Zeiss confocal
AFM measurements work at the first shot
Measuring single molecules demands highest resolution in imaging and force measurements, particularly in fluids
Long-term experiments demand the utmost stability and zero drift - an ideal closed-loop scanner is essential
NanoWizard II head on stage NanoWizard II setup
Biological samples require optical contrast enhancement methods like phase contrast and DIC - a real optical condenser is needed
Fluorescence techniques such as TIRF, FRET, FCS, FRAP, FLIM, Ca2+ response, and laser scanning microscopy require that the sample does not scan - only a cantilever tip-scanning AFM can provide this
The AFM and optical microscope must be software integrated and without interference - optical filters and an infrared light source allow truly simultaneous operation

JPK has followed these principles and provides the optimum BioAFM solution with the NanoWizard®II. The NanoWizard® has proven its performance in almost every research field, from nanomanipulation to cell adhesion measurements, from surface chemistry to DNA high resolution imaging, from bacteria to pharmaceuticals, from electrochemistry to polymer melting. Our continuously growing global user base and the scientific publication output of our customers are convincing proof of this.

Working in liquid demands that no sensitive parts be positioned below the sample level - a sample scanning approach is not suitable
All parts in contact with the sample must be easy to exchange, replace, and rigorously clean
The AFM must be completely sealed and offer different fluid cells for the full range of applications
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App/Tech reports
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Optimum results for all different applications, i.e. a large scan range, but also the highest resolution
Electronics, hardware, and software must allow user-defined experiments and integration with external equipment, e.g. electrical or optical devices
The entire spectrum of AFM modes and a comprehensive range of accessories are needed for complex experiments, e.g. for environmental control