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Cell Adhesion Studies
at the Nano Scale — March 30, 2005
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JPK Instruments AG introduces a new product for the study of
cellular adhesion phenomena. Until now the investigation of cell-cell
and cell-substrate interaction has been restricted to optical
methods capable of producing only qualitative results.
The CellHesion® Development Kit employs the scanning probe
technology to deliver quantitative and reproducible measurements.
JPK uses the high sensitivity of a nano-mechanical sensor to determine
the actual force of single cell adhesion and the "work of
removal" that is necessary to separate cells from specific
substrates or other cells. This tool can be used by biophysicists
and cell biologists to address fundamental biological and medical
questions in research fields such as morphogenesis, cancer development,
or interaction with biocompatible materials.
Available as an add-on to the NanoWizard® BioAFM, these capabilities
can additionally be combined with the nano-imaging, measuring,
and manipulation functions of the BioAFM. Furthermore, all functions
of an inverted optical microscope like phase contrast, DIC, fluorescence
and advanced imaging modes are simultaneously available, allowing
a direct overlay and comparison between the different techniques.
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