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Force Spectroscopy cell elasticity studies cell stiffness young's modulus live cell testing elastic properties cytosceleton cell-substrate interactions tether characteristics work of removal cell elasticity studies living cell experiments cell-cell interactions vesicles cell membrane tether formation single cell force spectroscopy live cell imaging cellular mechanics nanowizard add-on phagocytosis endocytosis nanotoxicity motor proteins cell-particle interactions photonic force microscopy living cell studies photonic force microscopes bead manipulation optical trap optical trapping force clamp force ramp mapping protein unfolding protein folding force extension profiles conformational transitions binding studies forcerobot table-top force mapping functionalized surfaces carbohydrates dendrimers lipids proteins rna dna single molecule studies force curves single molecule force spectroscopy force spectroscopes snom scatter type snom sers ters bleaching field enhancement quencing quantum dots scanning confocal imaging single molecule imaging optical spectroscopy tip assisted optics implants coatings biochips non transparent samples biomaterials soft matter cell chips patterned substrates shuttle stage upright optical microscopy opaque samples drug delivery nanolithography nanomanipulation phase imaging contact mode live cell imaging tip scanning tip scanner optical integration in-situ-imaging Atomic Force Microscope, Atomic Force Microscopes particle detection particle tracking cell adhesion cell mechanics AFM / BioAFM Cellular Adhesion / Cytomechanics Optical Tweezers / 3D Particle Tracking